Education:
1975 MsC in Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava
1975-1979 Graduate studies Physical Chemistry, Insitute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia;
1978 RNDr. Degree in Physical Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia;
1980-1982 Postgraduate studies in Biophysics, Faculty of Mathematics and Physics, Comenius University, Bratislava, Slovakia;
1982 PhD in Physical Chemistry, Faculty of Chemical Technology, Slovak University of Technology in Bratislava, Slovakia;
1983-1984 Postdoctoral fellowship at Department of Chemistry, State University of New York, CESF, Syracuse, N. Y., USA.
Research Interests:
■ modeling of protein-protein and protein-ligand interactions;
■ stucture and conformations of carbohydrates, proteins, nucleic acids and other biomacromolecules;
■ bioinformatics, chemoinformatics and glycomics;
■ molecular, drug and nanoparticle design,
■ quantum-chemical structural studies using DFT;
■ high-throughput virtual screening;
■ modeling of amyloid supramolecular complexes;
■ molecular dynamics and coarse-grained simulation;
■ high-performance high-throughput grid computing.
Positions:
1979-1984 Research assistant and research scientist, Department of Biophysics, Institute of Neurobiology, SlovakAcademy of Sciences, Kosice, Slovakia;
1984-2013 Research and later (1986) Senior Research Scientist, Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia;
2013-current Research Scientist, Center for Interdisciplinary Biosciences, Safarik University, Kosice.
Visiting Scientist Positions Abroad:
1990-2018 Max Planck Institute for Medical Research, Heidelberg, Germany;
New Jersey Institute of Technology, Newark, New Jersey, USA;
German Cancer Research Institute, Heidelberg, Germany
GlycoDesign Inc., Toronto, Ontario, Canada;
LIT JINR, Dubna, Russian Federation.
Academic Background:
1975 MsC in Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava
1975-1979 Graduate studies Physical Chemistry, Insitute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia;
1978 RNDr. Degree in Physical Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia;
1980-1982 Postgraduate studies in Biophysics, Faculty of Mathematics and Physics, Comenius University, Bratislava, Slovakia;
1982 PhD in Physical Chemistry, Faculty of Chemical Technology, Slovak University of Technology in Bratislava, Slovakia;
1983-1984 Postdoctoral fellowship at Department of Chemistry, State University of New York, CESF, Syracuse, N. Y., USA.
Current Projects:
PI:
2007-2008: APVV SK-MAD 013-06-Hungary OMFB-01261/2007 „Development of a Virtual laboratory for highthroughput ligand and receptor-based molecular screening”;
2007-2009: VEGA-2/7053/27: “Molecular modeling of drug-dendrimer interactions“;
2011-2013: SAS Slovakia – NSC Taiwan Joint Research Project: “Computational approaches to study structure, folding and interactions of biopolymers”.
Team Member:
2009-2015 EU SF ITMS 26220120021 (2009-2011);
EU SF ITMS 26220120033 (2010-2013);
EU SF ITMS 26110230061(2012-2013);
EU SF ITMS 26110230178 (2013-2015);
2007-2010 APVV-0514-06 – PI: P. Kutschy, Safarik University, Kosice;
2011-2014 APVV-0171-10 – PI: P. Kopčanský, IEP SAS, Kosice;
2011-2015 EU SF/ITMS 26210120002 Coordinator of SAS project activities for Eastern Slovakia in “Slovak Infrastructure for High-Performance Computing” National Project;
2013-2016 EU FP7 project CELIM 316310 “Fostering excellence in multiscale cell imaging” ; PI P. Miškovský, Safarik Unmiversity, Kosice.
Published more than 50 articles resulting in more than 1100 references and H-index 19 (WOS)
List of 10 recent publications:
1. K. Siposova, T. Kozar, M. Stupakova and A. Musatov: Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. Colloids Surf B Biointerfaces, 197, 111428 (2021) doi:10.1016/j.colsurfb.2020.111428
2. E. Sedlak, T. Kozar and A. Musatov: The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase. Cells, 9(12) (2020) doi:10.3390/cells9122588
3. M. Petrencakova, R. Varhac, T. Kozar, M. Nemergut, D. Jancura, M. S. Schwer and E. Sedlak: Conformational properties of LOV2 domain and its C450A variant within broad pH region. Biophys Chem, 259, 106337 (2020) doi:10.1016/j.bpc.2020.106337
4. M. Petrencakova, F. Filandr, A. Hovan, G. Yassaghi, P. Man, T. Kozar, M. S. Schwer, D. Jancura, A. Pluckthun, P. Novak, P. Miskovsky, G. Bano and E. Sedlak: Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation. Sci Rep, 10(1), 4119 (2020) doi:10.1038/s41598-020-60861-2
5. R. Zhang, N. Zhang, M. Mohri, L. Wu, T. Eckert, V. B. Krylov, A. Antosova, S. Ponikova, Z. Bednarikova, P. Markart, A. Gunther, B. Norden, M. Billeter, R. Schauer, A. J. Scheidig, B. N. Ratha, A. Bhunia, K. Hesse, M. A. Enani, J. Steinmeyer, A. K. Petridis, T. Kozar, Z. Gazova, N. E. Nifantiev and H. C. Siebert: Nanomedical Relevance of the Intermolecular Interaction Dynamics-Examples from Lysozymes and Insulins. ACS Omega, 4(2), 4206-4220 (2019) doi:10.1021/acsomega.8b02471
6. K. Stroffekova, S. Tomkova, V. Huntosova and T. Kozar: Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels. Photodiagnosis Photodyn Ther, 28, 38-52 (2019) doi:10.1016/j.pdpdt.2019.08.016
7. K. Siposova, E. Sedlak, T. Kozar, M. Nemergut and A. Musatov: Dual effect of non-ionic detergent Triton X-100 on insulin amyloid formation. Colloids Surf B Biointerfaces, 173, 709-718 (2019) doi:10.1016/j.colsurfb.2018.10.039
8. K. Siposova, T. Kozar, V. Huntosova, S. Tomkova and A. Musatov: Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin. Biochim Biophys Acta Proteins Proteom, 1867(3), 259-274 (2019) doi:10.1016/j.bbapap.2018.10.002
9. J. Ulicny and T. Kozar: Roadmap for Computer-Aided Modeling of Theranostics and Related Nanosystems. EPJ Web of Conferences, 173, 05017 (2018) doi:10.1051/epjconf/201817305017
10. K. Kopcova, L. Blascakova, T. Kozar, D. Jancura and M. Fabian: Response of Heme Symmetry to the Redox State of Bovine Cytochrome c Oxidase. Biochemistry, 57(28), 4105-4113 (2018) doi:10.1021/acs.biochem.8b00459