Assoc. Prof. Daniel Jancura, PhD.

Associate professor at Department of Biophysics, Faculty of Natural Sciences, Safarik University in Kosice (UPJS), PhD. degree in Biophysics (1999), Comenius University in Bratislava (Slovakia), associate professor in Biophysics at UPJS from 2009. Specialist in molecular biophysics and molecular bioenergetics, recent research interests: structure and stability of biomacromolecules and their complexes with low molecular ligands, construction and characterization of lipoprotein based drug delivery systems, catalytical mechanism of cytochrome c oxidase.

Education

1976 – 84 Elementary school, ZS Hrnčiarska Humenné
1984 – 88 High school, Gymnázium Humenné
1988 – 93 Safarik University Kosice (Slovakia) – MSc. in Biophysics
1993 – 97 Safarik University Kosice – PhD study in Biophysics
1999 Comenius University Bratislava (Slovakia)- Defence of PhD thesis

Professional positions

1997 – 1999 Assistant professor, Department of Biophysics, Safarik University Kosice
2002 – 2009 Assistant professor, Department of Biophysics, Safarik University Kosice
2009 – Associate profesor, Department of Biophysics, Safarik University, Kosice

Foreign stays

1993 Dipartimento de Biochimica, Universita Bologna (Italy)
1996 – 1997 Instituto de Estructura de la Materia, CSIC , Madrid (Spain)
1999 – 2002 Department of Biochemistry & Cell biology, Rice University, Houston (USA)
2005 Department of Biochemistry & Cell biology, Rice University, Houston (USA)
2010 Department of Biochemistry & Cell biology, Rice University, Houston (USA)
2011 Department of Biochemistry & Cell biology, Rice University, Houston (USA)

Professional orientation

Optical spectroscopy (UV.VIS absorbance, fluorescence, Raman) and microcalorimetry of biomacromolecules and their complexes with biological imporatnts ligands
Construction and characterization of lipoprotein based drug delivery systems
Molecular mechanisms of photodynamic therapy
Catalytical mechanism of cytochrome c oxidase

Number of articles in CC journals : 35
Number of SCI citations : 208

Hobby

Sport (football, tenis, basketball)
Literature (scientific literature, politics, economy, Music (60‘s)

List of CC publications

  1. G. Fabriciová, P. Miškovský, D.Jancura, E. Kočišová and V. Lisý. Conformational transitions of poly ( dI-dC) as studied by classical Raman spectroscopy. Gen. Physiol. Biophys. 14, 203 216 (1995).
  2. D.Jancura, S. Sánchez-Cortés, E. Kočišová, A Tinti, P. Miškovský and A. Bertoluzza. Surface-enhanced resonance Raman spectroscopy of hypericin and emodin on silver colloids. SERRS and NIR FTSERS study. Biospectroscopy 1, 265 273 (1995).
  3. S. Sánchez-Cortes, P. Miškovský, D. Jancura and A. Bertoluzza. Specific interactions of antiretroviraly active drug hypericin with DNAas studied by surface-enhanced resonance Raman spectroscopy. J. Phys. Chem. 100, 1938–1944 (1996).
  4. S. Sánchez-Cortés, D. Jancura, P. Miškovský and A. Bertoluzza. Near infrared surface- enhanced Raman spectroscopic study of antiretroviraly drug hypericin and emodin in aqueous silver colloids. Spectrochimica Acta Part A 53, 769–779 (1997).
  5. G. Wheeler, P. Miškovský, D. Jancura and L. Chinsky. A study of metalloporphyrin polynucleotide interactions by microcalorimetry and circular dichroism. J. Biomol. Str. Dyn. 15, 967–985 (1998).
  6. P. Miškovský, D. Jancura, S. Sánchez-Cortés, E. Kočišová and L. Chinsky. Antiretroviraly active drug hypericin binds the IIA subdomain of human serum almumin. Resonance Raman and surface-enhanced Raman spectroscopy study. J.Am. Chem. Soc. 120, 6374–6379 (1998).
  7. D. Jancura, S. Sánchez-Cortes, P. Miškovský, L. Rivas, J. Staničová and J.V. García-Ramos. Surface-enhanced resonace Raman spectroscopy of hypocrellin A An effect of excitation wavelength and pH . Spectrochimica Acta Part A 54, 1519–1526 (1998).
  8. G. Fabriciová, P. Miškovský, D. Jancura and V. Lisý. Charcterization of low salt and high salt conformation of poly (dI-dC) by hydrogen-deuterium exchange kinetics A classical Raman spectroscopy study. J. Biomol. Str. Dyn. 16, 281–288 (1998).
  9. G. Fabriciová, P. Miškovský, D. Jancura, V. Lisý and L. Chinsky. Conformatiponal study of poly (dI-dC): Hydrogen-deuterium exchange and low frequency resonance Raman spectroscopy. J. Mol. Str. 480–481, 449–453 (1999).
  10. Kočišová, D. Jancura, S. Sánchez-Cortés, P. Miškovský, L. Chinsky and J.V. García- Ramos. Interaction of antiviral and antitumoral photoactive drug hypocrellin A with human serum albumin. J. Biomol. Str. Dyn. 17, 111–120 (1999).
  11. M. Fabian, D. Jancura and G. Palmer. Two sites of interaction of anions with cytocrome a in oxidized bovine cytochrome c oxidase. J. Biol. Chem. 279, 16170–16177 (2004).
  12. M. Fabian, L. Skultety, D. Jancura and G. Palmer. Implications of ligand binding studies for the catalytic mechamism of cytochrome c oxidase. BBA-Bioenergetics 1655,298–305 (2004).
  13. J.Hritz, J. Ulicny, A. Laaksonen, D. Jancura and P. Miskovsky. Molecular interaction model for the C1B domain of protein kinase C in the complex with its activator phorbol 12-myristate 13– acetate in water solution and lipid bilayer. J.Med.Chem. 47, 6547–6555 (2004).
  14. M. Antalik, D. Jancura, G. Palmer and M. Fabian. A role for the protein in internal electron transfer to the catalytic center of cytochrome c oxidase. Biochemistry 44, 14881–14889 (2005).
  15. S. Kascakova, M.Refregiers, D. Jancura, F. Sureau, J.C. Maurizot and P. Miskovsky. Fluorescence spectroscopic study of hypericin-photosensitized oxidation of low-density lipoproteins. Photochem.Photobiol. 81, 1395–1403 (2005).
  16. M. Fabian, D. Jancura, M. Bona, A. Musatov, M. Baran and G. Palmer. Influence of reduction of heme a and CuA on the oxidized catalytic center of cytochrome c oxidase: Insight from organic solvents. Biochemistry 45, 4277–4283 (2006).
  17. S. Kocanova, T. Hornakova, J. Hritz, D. Jancura, D. Chorvat jr., A. Mateasik, J. Ulicny, M. Refregiers, J.C. Maurizot and P. Miskovsky. Characterization of the interaction of hypericin witk protein kinase C in U-87 MG human glioma cells, Photochem. Photobiol. 82, 720–728 (2006).
  18. D. Jancura, M. Antalik, V. Berka, G. Palmer and M. Fabian. Filling the catalytic site of cytochrome c oxidase with electrons : Reduced CuB facilitates internal electron transfer to heme a3. J. Biol. Chem. 281, 20003–20010 (2006).
  19. D. Jancura, V. Berka, M. Antalik, J. Bagelova, R.B. Gennis, G. Palmer and M. Fabian. Spectral and kinetic equivalence of oxidized cytochrome c oxidase as isolated and „activated“ by reoxidation. J. Biol. Chem. 281, 30319–30325 (2006).
  20. M. Savko, S. Kascakova, P. Mojzes, D. Jancura, P. Miskovsky and J. Ulicny. Ground and excited state properties of naphthazarin: Absorption spectroscopy and theoretical modeling study, J.Mol.Struct. THEOCHEM 803, 79–87 (2007).
  21. S. Kascakova, Z. Nadova, A. Mateasik, J. Mikes, V. Huntosova, M. Refregiers, F. Sureau, J.C. Maurizot, P. Miskovsky and D. Jancura. High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL. Photochem. Photobiol. 84, 120–127 (2008).
  22. P. Gbur, R. Dedic, D. Jancura, P. Miskovsky and J. Hala. Time resolved luminescence and singlet oxygen formation under illumination of hypericin in acetone. Journal of Luminescence, 128, 765–767 (2008),
  23. G.Lajos, D.Jancura, P.Miskovsky, J.V.Garcia-Ramos and S.Sanchez-Cortes. Surface-enhanced fluorescence and Raman scattering study of antitumoral drug hypericin: An effect of aggregation and self-spacing depending on pH. J.Phys.Chem. C 112, 12974–12980 (2008).
  24. P. Gbur, R. Dedic, D. Chorvat jr., P. Miskovsky, J. Hala and D. Jancura. Time resolved luminescence and singlet oxygen formation after illumination of hypericin-low-density lipoproteins complex. Photochem. Photobiol. 85, 816–8223 (2009).
  25. G. Lajos, D. Jancura, P. Miskovsky, J.V. Garcia-Ramos and S. Sanchez-Cortes. Interaction of the photosensitizer hypericin with low-density lipoproteins and phosphatidylcholine: A surface – enhanced Raman scattering and surface-enhanced fluorescence study. J. Phys. Chem. C 113, 7147–7154 (2009).
  26. V. Huntosova, L. Alvarez, L. Bryndzova, Z. Nadova, D. Jancura, L. Buriankova, S. Bonneau, D. Brault, P. Miskovsky and F. Sureau. Interaction dynamics of hypericin with low-density lipoproteins and U-87-MG cells. Int. J. Pharmaceutics 389, 32–40 (2010).
  27. L. Buriankova, Z. Nadova, D. Jancura, M. Refregiers, I. Yousef, J. Mikes and P. Miskovsky. Synchrotron based Fourier-transform infrared microspectroscopy as sensitive technique for the detection of early apoptosis in U-87 MG cells. Laser Phys. Lett. 7, 613–620 (2010).
  28. L. Buriankova, D. Buzova, D. Chorvat jr., F. Sureau, D. Brault, P. Miskovsky and D. Jancura. Kinetics of hypericin association with low-density lipoproteins. Photochem. Photobiol. 87, 56–63 (2011).
  29. G. Bano, J. Stanicova, D. Jancura, J. Marek, M. Bano, J. Ulicny, A. Strejckova and P. Miskovsky. On the diffusion of hypericin in dimethylsulfoxide/water mixtures-The effect of aggregation. J. Phys. Chem. B115, 2417–2423 (2011).
  30. V. Huntosova, D. Buzova, D. Petrovajova, P. Kasak, Z. Nadova, D. Jancura, F. Sureau and P. Miskovsky. Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells. Int. J. Pharmaceutics 436, 463–471 (2012).
  31. B. Buzova, V. Huntosova, P. Kasak, D. Petrovajova, J. Joniova, L. Dzurova, Z. Nadova, F. Sureau, P. Miskovsky and D. Jancura. Towards increased selectivity of drug delivery to cancer cells: development of a new LDL-based nanodelivery system for hydrophobic photosenzitizers. Proceedings of SPIE vol. 8460, Biosensing and Nanomedicine V, 84600U (2012).
  32. A. Strejckova, J. Stanicova, D. Jancura, P. Miskovsky and G. Bano. Spatial orientation and electric-field-driven transport of hypericin inside of bilayer lipid membranes. J. Phys. Chem. B 117, 1280–1286 (2013).
  33. E. Lopez-Tobar, M. Antalik, D. Jancura, M.V. Canamares, A. Garcia-Leis, D. Fedunova, G. Fabriciova and S. Sanchez-Cortes. Adsorption and detection of amyloid marker thioflavin T on Ag nanoparticles by surface-enhanced Raman scattering. J. Phys. Chem. C 117, 3996–4005 (2013).
  34. D. Petrovajova, D. Jancura, P. Miskovsky, D. Chorvat jr., A. Chorvatova, X. Ragas, M. Garcia-Diaz, S. Nonell and Z. Nadova. Monitoring of singlet oxygen luminescence and mitochondrial autofluorescence after illumination of hypericin/mitochondria complex: a time-resolved study. Laser Physics Letters 10, art. no. 075609 (2013).
  35. D. Buzova, P. Kasak, P. Miskovsky and D. Jancura. Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol. Gen. Phys. Bioph. 32, 201–208 (2013).